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Shouichi Higashi Selected Research

cholesteryl sulfate

12/2017Matrix metalloproteinase-7 induces homotypic tumor cell aggregation via proteolytic cleavage of the membrane-bound Kunitz-type inhibitor HAI-1.
4/2006Binding of active matrilysin to cell surface cholesterol sulfate is essential for its membrane-associated proteolytic action and induction of homotypic cell adhesion.

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Shouichi Higashi Research Topics

Disease

17Neoplasms (Cancer)
12/2017 - 11/2003
7Colonic Neoplasms (Colon Cancer)
12/2017 - 11/2003
6Carcinoma (Carcinomatosis)
05/2011 - 10/2003
4Neoplasm Metastasis (Metastasis)
12/2017 - 11/2003
4Breast Neoplasms (Breast Cancer)
06/2015 - 06/2005
1Stomach Neoplasms (Stomach Cancer)
12/2006
1Clear Cell Adenocarcinoma
02/2006
1Lung Neoplasms (Lung Cancer)
06/2005
1Fibrosarcoma
06/2003

Drug/Important Bio-Agent (IBA)

6Matrix Metalloproteinase 7 (Matrilysin)IBA
12/2017 - 11/2003
4Membrane Proteins (Integral Membrane Proteins)IBA
12/2017 - 11/2003
4Proteins (Proteins, Gene)FDA Link
06/2015 - 06/2005
3Laminin (Merosin)IBA
06/2015 - 05/2011
3tumor-derived adhesion factorIBA
06/2014 - 10/2003
3Matrix Metalloproteinases (MMPs)IBA
03/2014 - 04/2006
3Fibronectins (Fibronectin)IBA
01/2012 - 12/2008
2cholesteryl sulfateIBA
12/2017 - 04/2006
2CollagenIBA
08/2014 - 01/2012
2Conditioned Culture MediaIBA
08/2014 - 06/2005
2Insulin-Like Growth Factor Binding ProteinsIBA
04/2012 - 10/2003
2matriptaseIBA
12/2006 - 06/2005
2Serine Proteases (Serine Protease)IBA
12/2006 - 06/2005
1Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA
12/2017
1Amino AcidsFDA Link
12/2017
1Tumor Biomarkers (Tumor Markers)IBA
06/2015
14- (5- benzo(1,3)dioxol- 5- yl- 4- pyridin- 2- yl- 1H- imidazol- 2- yl)benzamideIBA
08/2014
1LY-2157299IBA
08/2014
1Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA
08/2014
1Transforming Growth Factors (Transforming Growth Factor)IBA
08/2014
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
06/2014
1IntegrinsIBA
06/2014
1LigandsIBA
06/2014
1Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)IBA
02/2014
1Pharmaceutical PreparationsIBA
03/2013
1Glycoproteins (Glycoprotein)IBA
04/2012
1C-Type Lectins (C-Type Lectin)IBA
03/2009
1Recombinant ProteinsIBA
03/2009
1Annexin A2 (Annexin II)IBA
10/2008
1Tissue Plasminogen Activator (Alteplase)FDA Link
10/2008
1Peptides (Polypeptides)IBA
10/2008
1Matrix Metalloproteinase 3 (Stromelysin 1)IBA
12/2006
1betadex (beta-cyclodextrin)IBA
04/2006
1insulin-like growth factor binding protein-related protein 1IBA
02/2006
1Culture MediaIBA
06/2005
1Enzyme Precursors (Zymogens)IBA
06/2005
1Epidermal Growth Factor (EGF)IBA
06/2005
1TrypsinIBA
06/2005
1Cadherins (E-Cadherin)IBA
11/2003
1EnzymesIBA
11/2003
1Insulin-Like PeptidesIBA
10/2003
1progelatinaseIBA
06/2003
1Concanavalin AIBA
06/2003